Compound testing in mice, Drug Validation Initiative and Pre-clinical studies

Patricia Cogram, PhD, Project coordinator, PI

University of Chile

2018 – $50,000, Testing 5 new compounds

2019 – $76,600, Gene Therapy grant (TCF4)

2020 – $71,600, MECP2

2021 – $22,000, Compound from Tetra pharmaceuticals (working in Fragile X)

2021 – $19,280, Microbiome/Neuren compound

Different pharmacological compounds will be tested using the Pitt Hopkins Syndrome (PTHS) mouse model to assess their impact on neuronal migration, establishment of connectivity, synaptic function and behavior. Measurements will be carried out at different levels, ranging from single cells to behavioral studies to explore the mechanisms of drug effect in PTHS.