If you know Chloe, you know the joy she brings to our family and to everyone around her. Her smile, determination, and sweet personality have impacted more people than she will ever know.

Chloe has Pitt Hopkins Syndrome, a rare genetic disorder caused by changes in the TCF4 gene. Every day, we pray for her continued growth and development and for a future filled with possibilities we may not even be able to imagine today.

And for the first time, that future feels a little different.

In 2026, the first-ever gene therapy clinical trial for Pitt Hopkins Syndrome began treating patients. The investigational therapy is designed to address the underlying cause of Pitt Hopkins by providing functional copies of the TCF4 gene. For families like ours, this is an incredible milestone and a source of tremendous hope.

We don’t know what this therapy, or the research that follows it, will ultimately mean for Chloe. But we do know that progress like this only happens because families, researchers, donors, and communities choose to keep pushing forward.

That’s why we’re raising money for the Pitt Hopkins Research Foundation. We are incredibly grateful for the way our friends and family have loved Chloe, encouraged our family, and celebrated every milestone alongside us. Now we’re asking you to join us in helping change what the future could look like—not just for Chloe, but for everyone living with Pitt Hopkins Syndrome.

Every donation helps support research, clinical development, and the pursuit of better treatments.

Thank you for loving Chloe, believing in her, and giving us hope for what’s ahead.