Title:  Common Pathophysiology in Multiple Mouse Models of Pitt–Hopkins Syndrome

Authors:  Courtney Thaxton, Alexander D. Kloth, Ellen P. Clark, Sheryl S. Moy, Raymond A. Chitwood and Benjamin D. Philpot

The Journal of Neuroscience, 24 January 2018, 38(4):918-936;



Full paper here:PTHS_JNS_Philpot

Title:  The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A

Authors: Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild and Tõnis Timmusk



Title: Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

Authors:  Andrew J. Kennedy, Elizabeth J. Rahn, Brynna S. Paulukaitis, Katherine E. Savell, Holly B. Kordasiewicz, Jing Wang, John W. Lewis, Jessica Posey, Sarah K. Strange, Mikael C. Guzman-Karlsson, Scott E. Phillips, Kyle Decker, S. Timothy Motley, Eric E. Swayze, David J. Ecker, Todd P. Michael, Jeremy J. Day, J. David Sweat

Cell Reports 16, 1–20 September 6, 2016



Title:  Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons

Authors:  Mitchell D’Rozario, Ting Zhang, Edward A. Waddell, Yonggang Zhang, Cem Sahin, Michal Sharoni, Tina Hu, Mohammad Nayal, Kaveesh Kutty, Faith Liebl, Wenhui Hucorrespondenceemail, Daniel R. Marenda

Cell Reports, Volume 15, Issue 2, p386–397, 12 April 2016


Title: Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1

Authors: Matthew D. Rannals, Gregory R. Hamersky, Stephanie Cerceo Page, Morganne N. Campbell, Aaron Briley, Ryan A. Gallo, BaDoi N. Phan, Thomas M. Hyde, Joel E. Kleinman, Joo Heon Shin, Andrew E. Jaffe, Daniel R. Weinberger, Brady J. Maher

Neuron, Volume 90, Issue 1, p43–55, 6 April 2016



Title:  Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless

Authors: Laura Tamberg, Mari Sepp, Tõnis Timmusk and Mari Palgi*

© 2015. Published by The Company of Biologists Ltd | Biology Open (2015) 00, 1-10 doi:10.1242/bio.014696

See link to PDF of article:  Tamberg_BiolOpen2015


Title:  Pitt–Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription

Author:  J David Sweatt

Citation: Experimental & Molecular Medicine (2013) 45, e21; doi:10.1038/emm.2013.32
Published online 3 May 2013